冯国平 博士

 

 

 

 

 

 

 

冯国平博士:浙江医科大学本科毕业,上海第二医科大学硕士、纽约州大学博士、华盛顿大学-圣路易博士后;曾任美国杜克大学神经生物学系助理教授,终身副教授;现任麻省理工学院大脑与认知科学系McGovern大脑研究所Poitras讲席教授,兼职华东师范大学特聘(国家千人计划引进)教授。研究方向:研究神经突触和环路功能及精神疾病发生机理,创建神经系统研究新技术。

 

代表性论文:

  1. Feng, G., Deak, P., Chopra, M. and Hall, L.M. (1995) Cloning and functional analysis of tipE: A novel membrane protein which enhances Drosophila para sodium channel function. Cell 82:1001-1011.
  2. Feng*, G., Tintrup*, H., Kirsch, J., Nichol, M., Kuhse, J., Betz, H. and Sanes, J.R. (1998) Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science 282:1321-1324. *co-first authors
  3. Feng, G., Hood, R., Bernstein, M., Keller-Peck, C., Nguyen, Q., Wallace, M., Nerbonne, J.M., Litchman, J.W. and Sanes, J.R (2000). Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28:41-51.
  4. Parker, M.J., Zhao, S., Bredt, D.S., Sanes, J.R., and Feng, G. (2004) PSD93 regulates synaptic stability at neuronal cholinergic synapses. J. Neurosci. 24:378-88.
  5. Finn, A.J., Feng*, G., and Pendergast*, A.M. (2003) Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. Nat. Neurosci. 6:717-23. *co-corresponding authors.
  6. Young, P., Nie, J., Wang, X., McGlade, CJ, Rich, MM, and Feng, G. (2005) Interaction of ErbB2 with LNX1 E3 ubiquitin ligase: potential role in the development of perisynaptic Schwann cells at the neuromuscular junction. Mol. Cell. Neurosci. 30:238-48.
  7. Ficklin, MB., Zhao, S., and Feng, G. (2005) Ubiquilin-1 regulates nicotine-induced upregulation of neuronal nicotinic acetylcholine receptors. J. Biol. Chem. 280:34088-34095.
  8. Wang, H., Peca, J., Matsusaki, M., Matsusaki, K., Noguchi, J., Qiu, L., Wang, D., Zhang, F., Boyden, E., Deisseroth, K., Kasai, H., Hall, WC., Feng*, G., and Augustine*, GJ (2007) High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proc Natl Acad Sci U S A. 104:8143-8148. *co-corresponding authors
  9. Arenkiel, B.A., Peca, J., Davison, I.G., Feliciano, C., Deisseroth, K., Augustine, G.J., Ehlers, M.D., and Feng, G.(2007) Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2. Neuron 54:205-218.
  10. Lu, Z, Je, H-S., Young, P., Groos, J., Lu, B., and Feng, G. (2007) Regulation of Synaptic Growth and Maturation by a Synapse-Associated E3 Ubiquitin Ligase at the Neuromuscular Junction. J Cell Biol. 177:1077-1089.
  11. Welch, JM., Lu, J., Rodriguiz, RM., Trotta, NC., Peca, J., Ding, J-D., Feliciano, C., Chen, M., Adams, JP., Luo, J., Dudek, SM., Weinberg, RJ., Calakos, N., Wetsel, WC., and Feng, G. (2007) Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice. Nature 448:894-900.
  12. Young, P., Qiu, L., Wang, D., Zhao, S., Gross, J., and Feng, G. (2008). Single-neuron labeling with inducible cre-mediated knockout in transgenic mice. Nature Neurosci. 11:721-8.
  13. Peca J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TY, Lascola CD, Fu Z and Feng G. (2011) Shank3mutant mice display autistic-like behaviours and striatal dysfunction. Nature, 472:437-42.
  14. Halassa MM, Siegle JH, Ritt JT, Ting JT, Feng* G, Moore* CI. (2011) Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles. Nat Neurosci. 14:1118-20. *co-corresponding authors.
  15. zhao, S., Ting, JT., Atallah HE., Qiu, L., Tan, J., Gloss, B., Augustine, GJ., Deisseroth, K., Luo, M., Graybiel, AM. and Feng, G. (2011) Cell-type Specific Optogenetic Mice for Dissecting Neural Circuitry Function. Nature Methods 8:745-752.
  16. Chen Q, Cichon J, Wang W, Qiu L, Lee S-JR, Campbell NR, DeStefino N, Fu Z, Yasuda R, Looger LL, Arenkiel BR, Gan W-B and Feng G. (2012) Imaging Neural Activity Using Thy1-GCaMP Transgenic mice. Neuron 76:297-308.
  17. Burguière E, Monteiro P, Feng G, Graybiel AM. (2013) Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science 340:1243-6.
  18. Pinto L, Goard MJ, Estandian D, Xu M, Kwan AC, Lee S-H, Harrison TC, Feng G, and Dan Y. (2013) Fast Modulation of Visual Perception by Basal Forebrain Cholinergic Neurons. Nat. Neurosci. 16:1857-63.