汪小京 博士

脑功能基因组学重点实验室PI
电话:021-20595003
Email: xjwang@nyu.edu

 

 

 

 

研究方向
计算神经科学、决策及工作记忆

 

个人简历

汪小京教授现任纽约大学神经科学教授,及物理与数学兼职教授,并任纽约大学斯沃茨理论神经科学中心联合主任。他同时是上海纽约大学科研副校长、华东师范大学- 纽约大学脑与认知科学联合研究中心(上海纽约大学)主任。2012年至2014年,汪教授担任上海纽约大学首位教务长。汪教授于2012年加入纽约大学,此前曾任耶鲁大学神经生物学教授、耶鲁大学斯沃茨理论神经科学中心主任、物理、应用数学系与心理学系兼职教授。

汪教授是理论与计算神经科学专家,研究重点是认知功能的脑机制,尤其以在工作记忆的细胞基础、决策的神经机制、大脑抑制神经元网络的研究而著称。他的团队开创了被称为“大脑CEO”的前额叶皮质神经网络模型研究。最近,汪教授的团队正创建大型脑的神经系统仿真模型,来深入研究认知、行为的脑机制和计算原理。

汪教授曾以最优成绩获得比利时布鲁塞尔大学的物理学学士学位与博士学位。他是阿尔弗雷德·斯隆研究学者奖、美国国家科学基金会CAREER奖、古根海姆纪念基金会学者奖、斯坦福大学行为科学高等研究中心学者奖获得者,并入选中国国家“千人计划”。此外,汪教授还是美国科学促进会会士。


代表性成果

Selected publications:

1.     Wei W, Wang X-J (2016) Downstream effect of ramping neuronal activity through synapses with short-term plasticity. Neural Comput. 28:652-666. doi:10.1162/NECO_a_00818

2.     Song HF*, Yang GR*, Wang X-J (2016) (* equal contribution) Training excitatory-inhibitory recurrent neural networks for cognitive tasks: A simple and flexible framework. PLoS Comp. Bio. 12:e1004792. doi:10.1371/journal.pcbi.1004792

3.     Wang X-J, Kennedy H (2016) Brain structure and dynamics across scales: in search of rules. Curr. Opin. in Neurobio. 37:92-98. doi:10.1016/j.conb.2015.12.010

4.     Sarma A, Masse NY, Wang X-J, Freedman DJ (2016) Task-specific versus generalized mnemonic representations in parietal and prefrontal cortices. Nature Neuroscience 19:143–149. doi:10.1038/nn.4168

5.     Wei W, Wang X-J (2015) Impact of membrane bistability on dynamical response of neuronal populations. Phys. Rev. E 92:032726. doi:10.1103/PhysRevE.92.0327265

6.     Yang GJ, Murray JD, Wang X-J, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A (2015) Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proc. Natl. Acad. Sci. USA 113:E219–E228. doi:10.1073/pnas.1508436113

7.     Lo C-C, Wang C-T, Wang X-J (2015) Speed-accuracy tradeoff by a control signal with balanced excitation and inhibition. Journal of Neurophysiology 114:650-661. doi:10.1152/jn.00845.2013

8.     Chaudhuri R, Knoblauch K, Gariel M-A, Kennedy H, Wang X-J (2015) A large-scale circuit mechanism for hierarchical dynamical processing in the primate cortex. Neuron 88, 419–431. doi:10.1016/j.neuron.2015.09.008

9.     Wei Z, Wang X-J (2015) Confidence estimation as a stochastic process in a neurodynamical system of decision making. J. Neurophys. 114, 99-113. doi:10.1152/jn.00793.2014

10.  Engel TA*, Chaisangmongkon W*, Freedman DJ, Wang X-J (2015) (* equal contribution). Choice-correlated activity fluctuations underlie learning of neuronal category representation. Nature Communications 6, 6454. doi:10.1038/ncomms7454

11.  Wei W, Rubin JE, Wang, X-J (2015) Role of the indirect pathway of the basal ganglia in perceptual decision making. J. Neurosci. 35, 4052-4064. doi:10.1523/JNEUROSCI.3611-14.2015

12.  Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole MW, Savic A, Yang GJ, Repovs G, Murray JD, Wang X-J, Huang X, Lui S, Krystal JH, Gong Q (2015) Early-course unmedicated schizophrenia patients exhibit elevated prefrontal connectivity associated with longitudinal change. J. Neurosci. 35, 267. doi:10.1523/JNEUROSCI.2310-14.2015

13.  Wang X-J, Krystal JH (2014) Computational Psychiatry. Neuron, 84:638-654. doi:10.1016/j.neuron.2014.10.018

14.  Murray JD, Bernacchia A, Freedman DJ, Romo R, Wallis JD, Cai X, Padoa-Schioppa C, Pasternak T, Seo H, Lee D, Wang X-J (2014) A hierarchy of intrinsic timescales across primate cortex. Nature Neuroscience 17, 1661. doi:10.1038/nn.3862

15.  Song HF, Kennedy H, Wang X-J (2014) Spatial embedding of structural similarity in the cerebral cortex. Proc. Natl. Acad. Sci. USA 111, 16580. doi:10.1073/pnas.1414153111

16.  Pereira J, Wang X-J (2014) A tradeoff between accuracy and flexibility in a working memory circuit endowed with slow feedback mechanisms. Cerebral Cortex. doi:10.1093/cercor/bhu202

17.  Yang GJ*, Murray JD*, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang X-J, Pearlson GD, Glahn DC, Anticevic A (2014) (* equal contribution) Altered global brain signal in schizophrenia. Proc. Natl. Acad. Sci. USA 111, 7438. doi:10.1073/pnas.1405289111

18.  Chaudhuri R, Bernacchia A, Wang X-J (2014) A diversity of localized timescales in network activity. eLife 2014;3:e01239. doi:10.7554/eLife.01239

19.  Ardid S, Wang X-J (2013) A Tweaking Principle for Executive Control: Neuronal Circuit Mechanism for Rule-Based Task Switching and Conflict Resolution. J. Neurosci. 33, 19504. doi:10.1523/JNEUROSCI.1356-13.2013

20.  Rigotti M, Barak O, Warden MR, Wang X-J, Daw ND, Miller EK, Fusi S (2013) The importance of mixed selectivity in complex cognitive tasks. Nature. doi:10.1038/nature12160

21.  Wang M, Yang Y, Wang C-J, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang X-J, Arnsten AFT (2013) NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron 77, 736-749. doi:10.1016/j.neuron.2012.12.032

22.  Engel TA, Wang X-J (2011) Same or different? A neural circuit mechanism of similarity based pattern-match decision making. J. Neurosci., 31: 6982-6996

23.  Rigotti M, Ben Dayan Rubin DD, Wang X-J and Fusi S (2010) Internal representation of task rules by recurrent dynamics: the importance of the diversity of neural responses. Front. Comput. Neurosci., 4: 24. doi: 10.3389/fncom.2010.00024

24.  Wang X-J (2010) Neurophysiological and computational principles of cortical rhythms in cognition. Physiol. Rev., 90: 1195-1268

25.  Lo C-C and Wang X-J (2006) Cortico-basal ganglia circuit mechanism for a decision threshold in reaction time tasks. Nature Neurosci., 9: 956-963

26.  Wong K-F and Wang X-J (2006) A recurrent network mechanism of time integration in perceptual decisions. J. Neurosci., 26: 1314-1328

27.  Wang X-J, Tegner J, Constantinidis C, Goldman-Rakic PS (2004) Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proc. Natl. Acad. Sci. (USA), 101, 1368-1373

28.  Renart A, Song P and Wang X-J (2003) Robust spatial working memory through homeostatic synaptic scaling in heterogeneous cortical networks. Neuron, 38, 473-485

29.  Wang X-J (2002) Probabilistic decision making by slow reverberation in cortical circuits.  Neuron, 36, 955-968

30.  Wang X-J (1999b) Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory. J. Neurosci. 19, 9587-9603.


Book chapters:

1.     Wang X-J (2013) The prefrontal cortex as a quintessential “cognitive-type” neural circuit: working memory and decision making. Principles of Frontal Lobe Function, Edited by DT Stuss and RT Knight, Second Edition, Cambridge University Press, pp. 226-248.

2.     Wang X-J (2013) Neuronal circuit computation of choice, In Neuroeconomics: Decision Making and the Brain, Second Edition, edited by P. W. Glimcher, C. F. Camerer, E Fehr and R. A. Poldrack. Academic Press, pp. 435-453.

3.     Wang X-J (2010) Prefrontal Cortex. in Handbook of Brain Microcircuits, Edited by G Shepherd and S Grillner, Oxford University Press, New York, pp. 46-56.

4.     Wang X-J (2009) Introduction to Theoretical Neuroscience (in Chinese). Chapter 53, in Neuroscience, edited by Han Jiseng (《神经科学》 (第三版),韩济生主编), Beijing University press, pp. 1004-1019.